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Overview

Anatomy

Pharmacology

The Department of Pharmacology was started in 1964, under the first head Dr. Aiman and is committed to high quality educational, research and service activities. Currently, our department provides quality education in Pharmacology and therapeutics for undergraduate and post graduate Medical, undergraduate Nursing and also for Allied health sciences students. Emphasis is placed to provide knowledge and skills required for rational, effective and safe use of drug therapy which make them competent health care professionals. Since 2008, the MBBS curriculum has incorporated applied pharmacology sessions as well as seminars and quizzes. The practical training curriculum has been recently updated to focus on clinical applications and basics of therapeutics.

The post graduate program (MD) was established in 1992 and the PhD program was started in 1989. We have implemented a well structured post graduate teaching program which includes external postings in the pharma industry, Bioequivalence unit, division of clinical research and training at St .John's research Institute and other institutions like CMC Vellore and NIMHANS. Till date, we have trained 60 MD students and 5 PhD students. Currently, we have grown to become one of the leading Pharmacology departments in the country.

The faculty of the Department are actively involved in quality multicentre research projects of national and international importance. Focus of research in the initial years was on preclinical studies in asthma, epilepsy and phase I studies but now the focus is on large multicentre projects on prevention and treatments of Non Communicable Diseases (NCDs). We have also developed a video to train clinical researchers on the constitution and functioning of Institutional Ethics Committees (IEC).

Our Team

Lead

Most Rev. Prakash Mallavarapu
Professor & Head

Professor & Head

Core Staff

Most Rev. Prakash Mallavarapu
Professor

Professor

Most Rev. Prakash Mallavarapu
Professor

Professor

Most Rev. Prakash Mallavarapu
Associate Professor

Associate Professor

Most Rev. Prakash Mallavarapu
Associate Professor

Associate Professor (Pharmacology).Dr. Deepak Kamath teaches undergraduate Pharmacology and is a university registere...

Most Rev. Prakash Mallavarapu
Associate Professor

Associate Professor

Most Rev. Prakash Mallavarapu
Assistant Professor

Assistant Professor

Services

No services listed.

Projects

S.I. No Project Title Project Lead Project Type Year of Initiation Status
1 Librexia AF is a randomized, double-blind, double-dummy, parallel group, active-controlled study to evaluate the efficacy and safety of milvexian versus apixaban in participants with atrial fibrillation. Dr. Denis Xavier 2024 2024 ongoing
2 Zilebesiran Cardiovascular Outcomes Trial (ZCVOT) Dr. Denis Xavier 2025 ongoing
3 Prevalence, Risk factors, COnsequences and opporTunities for prevention of falls in Elderly with select Chronic condiTions (PROTECT 2): A Mixed Methods Study Dr. Denis Xavier 2025 ongoing
4 Presentation, tReatments, challenges and Opportunities for optimal Treatments in the Elderly with select Chronic condiTions (PROTECT) Study Dr. Denis Xavier 2024 ongoing
5 Development and validation of a deprescribing tool relevant to the Indian context and evaluation of its effectiveness in reducing inappropriate polypharmacy in the elderly (ICMR-SRUM-NTF) Dr. Atiya R Faruqui 2023 ongoing
6 Pregnancy outcomes and it’s determinants at a tribal hospital in south India– A prospective cohort study (PREDICT) Dr. Denis Xavier 2022 ongoing
7 A Phase 3, Randomized, Double-Blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of an Oral Factor XIa Inhibitor, after a Recent Acute Coronary Syndrome (Milvexian ACS) Dr. Denis Xavier 2023 ongoing
8 Prospective Global Platform to Evaluate and Enhance Cognitive and Functional Trajectories after Stroke (PROSPECT) Dr. Denis Xavier 2024 ongoing
9 Impact, cost-effectiveness, and sustainability of a synergistic, multipronged, customized, low-cost intervention package (IP) to reduce cardiovascular disease (CVD) burden among diverse populations across India (ICMR-CAR) Dr. Denis Xavier 2024 ongoing
10 COLchicine and Thiamine in Heart Failure due to Ischemic Heart Disease (COLT-HF) Dr. Denis Xavier 2024 ongoing

Publications

Patient and caregiver reported facilitators of self-care among patients with chronic heart failure: report from a formative qualitative study

Groups and Associations D Y Kamath, K B Bhuvana, R S Dhiraj, D Xavier, K Varghese, L J Salazar, C B Granger, P Pais, B B Granger
Wellcome Open Reseach 2020
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One-year outcomes after discharge from noncardiac surgery and association between pre-discharge complications and death after discharge: analysis of the VISION prospective cohort study

Groups and Associations Pavel S Roshanov, Matthew TV Chan, Flavia K Borges, David Conen, CY Wang, Denis Xavier, PJ Devereaux
Anesthesiology 2024
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One-year Results of a Factorial Randomised Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery

Groups and Associations DI Sessler, D Conen, K Leslie, S Yusuf, E Popova, M Graham, A Kurz, JC Villar, M Mrkobrada, A Sigamani, BM Biccard, CS Meyhoff, JL Parlow, G Guyatt, D Xavier, MTV Chan, S Pettit, PJ Devereaux et al
Anesthesiology 2020
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Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial

Groups and Associations 149. Cukierman-Yaffe, Tali; Gerstein, Hertzel C; Colhoun, Helen M; Diaz, Rafael; García-Pérez, Luis-Emilio; Lakshmanan, Mark; Bethel, Angelyn; Xavier, Denis
Lancet Neurology 2020
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Medication errors in neonatal intensive care unit of a tertiary care hospital in South India: A prospective observational study

Groups and Associations B Prakadeesh Bharathi, Jeffrey Pradeep Raj, Kevin Saldanha, P N Suman Rao, D Padmini Devi
Indian Journal of Pharmacology 2020
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Polypill with or without Aspirin in Persons without Cardiovascular Disease

Groups and Associations 150. Yusuf, Salim; Joseph, Philip; Dans, Antonio; Gao, Peggy; Teo, Koon; Xavier, Denis; López-Jaramillo, Patricio; Yusoff, Khalid; Santoso, Anwar; Gamra, Habib
The New England Journal of Medicine 2020
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Situational Analysis of Practice Patterns and Challenges in Cardiovascular Disease Management - Qualitative Study

Groups and Associations Fathima Farah Naaz; Agrawal Twinkle; Nidhin Padmini; Xavier Denis
International Journal of Non Communicable Disease 2020
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Health and economic impact of air pollution in the states of India: the Global Burden of Disease Study 2019

Groups and Associations Anamika Pandey, Michael Brauer, Maureen L Cropper, Kalpana Balakrishnan, Prashant Mathur, Sagnik Dey, Burak Turkgulu, G Anil Kumar, Denis Xavier,
The Lancet Planetary Health 2021
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A qualitative, grounded theory exploration of the determinants of self-care behavior among Indian patients with a lived experience of chronic heart failure

Groups and Associations Deepak Y Kamath , K B Bhuvana , Luke Joshua Salazar , Kiron Varghese , Anant Kamath , Jyoti Idiculla 6, Prem Pais , Shruthi Kulkarni , Bradi B Granger , Denis Xavier
PLoS One 2021
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The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019

Groups and Associations Gagandeep Singh, Meenakshi Sharma, Avina Vongpradith, Han Y Wunrow, Denis Xavier, DK Shukla, K Srinath Reddy, Samiran Panda, Rakhi Dandona, Christopher JL Murray, Theo Vos, RS Dhaliwal, Lalit Dandona
The Lancet Global Health 2021
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Erectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the REWIND placebo-controlled randomised trial

Groups and Associations Harpreet S Bajaj, Hertzel C Gerstein, Purnima Rao-Melacini, Jan Basile, Helen Colhoun, Denis Xavier
The Lancet Diabetes and Endocrinology 2021
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Three weeks compared to seven-week run-in period length and the assessment of pre-randomization adherence: A study within a trial

Groups and Associations David Collister, Lawrence Mbuagbaw, Gordon Guyatt, PJ Devereaux, Karthik K Tennankore, Denis Xavier, et al
Contemporary Clinical Trials 2021
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Variations in knowledge, awareness and treatment of hypertension and stroke risk by country income level

Groups and Associations O'Donnell Martin; Hankey, Graeme J; Rangarajan, Sumathy; Chin, Siu Lim; Rao-Melacini, Purnima; Ferguson, John; Xavier Denis; Lisheng Liu; Zhang Hongye; Pais Prem
Heart 2020
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Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE): A Case-Control Study

Groups and Associations Conor Judge, Martin J O’Donnell, Graeme J Hankey, Sumathy Rangarajan, Siu Lim Chin, Purnima Rao-Melacini, John Ferguson, Andrew Smyth, Denis Xavier, Salim Yusuf, et al.
American Journal of Hypertension 2021
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Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation

Groups and Associations Anthony P Carnicelli, Sana M Al-Khatib, Denis Xavier, Frederik Dalgaard, Peter D Merrill, Daniel M Wojdyla, Basil S Lewis, Michael Hanna, John H Alexander, Renato D Lopes, Lars Wallentin, Christopher B Granger
Heart 2021
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Lowering cholesterol, blood pressure, or both to prevent cardiovascular events: results of 8.7 years of follow-up of Heart Outcomes Evaluation Prevention (HOPE)-3 study

Groups and Associations Jackie Bosch, Eva M Lonn, Lisheng Liu, Patricio Lopez-Jaramillo, Prem Pais, Denis Xavier, et al
European Heart Journal 2021
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The role and challenges of cluster randomised trials for global health

Groups and Associations Louis Dron, Monica Taljaard, Yin Bun Cheung, Rebecca Grais, Nathan Ford, Denis Xavier, et al
The Lancet Global Health 2021
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Randomised trials at the individual level

Groups and Associations Jay JH Park, Nathan Ford, Denis Xavier, Per Ashorn, Rebecca F Grais, Zulfiqar A Bhutta, et al
The Lancet Global Health 2021
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Urgently seeking efficiency and sustainability of clinical trials in global health

Groups and Associations Jay JH Park, Rebecca F Grais, Monica Taljaard, Jean B Nachega, Nathan Ford, Denis Xavier, et al
The Lancet Global Health 2021
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Safety of hydroxychloroquine in healthcare workers for COVID-19 prophylaxis

Groups and Associations Atiya R Faruqui, Denis Xavier, Sandhya K Kamat, Sujith J Chandy, Bikash Medhi, Raakhi K Tripathi, Yashashri C Shetty, et al
The Indian Journal of Medical Research 2021
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Efficacy and Safety of Dulaglutide in Older Patients: A post hoc Analysis of the REWIND trial

Groups and Associations Matthew C Riddle, Hertzel C Gerstein, Denis Xavier, William C Cushman, Lawrence A Leiter, et al
The Journal of Clinical Endocrinology and Metabolism 2021
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Prevalence of modifiable cardiovascular risk factors among coffee estate workers in rural South India (CARE)

Groups and Associations Sitarah Mathias, Akhil Xavier Joseph, Tanvi Jadhav, Denis Xavier
Indian Journal of Community Medicine 2021
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The utility of Vibratip in accurate identification of loss of protective sensation in the contralateral foot of patients admitted with a diabetic foot ulcer

Groups and Associations Elaina Pasangha, Belinda George, V Jayalakshmi, Padmini Devi, Vageesh Ayyar, Ganapathi Bantwal
Diabetes and Metabolic Syndrome 2021
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Hydroxychloroquine for SARS CoV2 Prophylaxis in Healthcare Workers – A Multicentric Cohort Study Assessing Effectiveness and Safety

Groups and Associations Badyal Dinesh, Chandy Sujith J, Chugh Preeta Kaur, Faruqui Atiya, Xavier Denis et al
Journal of the Association of Physicians of India 2021
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The Cost Implications of Dabigatran in Patients with Myocardial Injury After Non-Cardiac Surgery

Groups and Associations Andre Lamy, Wesley Tong, Rajibul Mian, Jessica Vincent, Denis Xavier, PJ Devereaux et al
American Journal of Cardiovascular Drugs 2021
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Measurement of hydroxychloroquine (hcq) in blood in asymptomatic healthcare workers on prophylactic regimen for covid-19 infection - an observational study

Groups and Associations Rajeev M. Patil., Denis Xavier., Srinivasa Reddy., Bhuvana KB., Mani Kandasamy., Arindam Mukhopadhyay and Saral Thangam
International Journal of Current Medical and Pharmaceutical Research 2021
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Use and adherence to oral anticoagulants in a tertiary care hospital

Groups and Associations Pradhyumna, M; Faruqui, Atiya Rehman; Joshi, Sunil S
Indian Journal of Vascular and Endovascular Surgery 2021
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Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis

Groups and Associations Philip Joseph, Gholamreza Roshandel, Peggy Gao, Prem Pais, Eva Lonn, Denis Xavier, on behalf of the Polypill Trialists’ Collaboration et al
Lancet 2021
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Topical Controlled Warm Oxygen Therapy Delivered Through a Novel Device (KADAM™) to Treat Diabetic Foot Ulcers: A Randomised Controlled, Open, Pilot Trial

Groups and Associations Anirudh V, Kamath DY, Ghosh S, Bhuvana KB, Sharma S, Maruthy K, Pais P, Xavier D
Indian Journal of Surgery 2021
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Anger or emotional upset and heavy physical exertion as triggers of stroke: the INTERSTROKE study

Groups and Associations Andrew Smyth, Martin O’Donnell, Graeme J Hankey, Sumathy Rangarajan, Patricio Lopez-Jaramillo, Denis Xavier, Salim Yusuf
European Heart Journal 2022
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Effect of a Perioperative Hypotension-Avoidance Strategy Versus a Hypertension-Avoidance Strategy on the Risk of Acute Kidney Injury: A Clinical Research Protocol for a Substudy of the POISE-3 Randomised Clinical Trial

Groups and Associations Garg AX, Cuerden M, Aguado H,… Denis Xavier et al.
Canadian journal of kidney health and disease 2022
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Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomised controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Groups and Associations Maura Marcucci, Thomas W Painter, David Conen, Kate Leslie, Vladimir V Lomivorotov, Daniel Sessler, Denis Xavier, PJ Devereaux
Trials 2022
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HbA1c Reduction in Dulaglutide-Treated Patients Irrespective of Duration of Diabetes, Microvascular Disease, and BMI: A Post Hoc Analysis From the REWIND Trial

Groups and Associations Anita YM Kwan, Hertzel C Gerstein, Jan Basile, Denis Xavier,
Diabetes Care 2022
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Predictors of Pharmacotherapy and Quality of Life Among Patients With Diabetic Foot Syndrome: A Cross-Sectional Study from a Tertiary Care Hospital in India

Groups and Associations E. Pasangha, B. George, K. B. Bhuvana and D. Padmini
Journal of Pharmacology and Pharmacotherapeutics 2022
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The Anti-Coronavirus Therapies (ACT)

Groups and Associations 176. John Eikelboom, Sumathy Rangarajan, Sanjit S Jolly, Emilie P Belley-Cote, … Prem Pais, Denis Xavier, Salim Yusuf.
Canadian Journal of Cardiology 2022
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Association of Lipids, Lipoproteins, and Apolipoproteins with Stroke Subtypes in an International Case Control Study (INTERSTROKE)

Groups and Associations Martin J O’Donnell, Matthew McQueen, Allan Sniderman, Guillaume Pare, … Denis Xavier, Prem Pais, Salim Yusuf.
Journal of Stroke 2022
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Tranexamic acid in patients undergoing noncardiac surgery

Groups and Associations 178. PJ Devereaux, Maura Marcucci, Thomas W Painter, David Conen, Chew Yin Wang, Denis Xavier, Gordon Guyatt, Salim Yusuf,
New England Journal of Medicine 2022
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Effects of aspirin in primary prevention of cardiovascular disease in people with chronic kidney disease: results of the TIPS3 trial

Groups and Associations Johannes FE Mann, Philip Joseph, Peggy Gao, Prem Pais, Denis Xavier,Jessica Tyrwhitt, Salim Yusuf
Kidney International 2022
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Role of Proxy Respondents in International Stroke Research: Experience of the INTERSTROKE Study

Groups and Associations Maria M Costello, Conor Judge, Catriona Reddin, Sumathy Rangarajan, Peter Langhorne, Denis Xavier, Andrew Smyth, Michelle D Canavan, Salim Yusuf
Neuroepidemiology 2022
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Meeting sustainable development goals via robotics and autonomous systems

Groups and Associations Solène Guenat, Phil Purnell, Zoe G. Davies, Lindsay C. Stringer, Giridhara Rathnaiah Babu, Muniyandi Balasubramanian, Bhuvana Kolar Bylappa, Bei Chen, Peta De Jager, Andrea Del Prete, Alessandro Di Nuovo, Cyril O. Ehi-Eromosele, Mehran Eskandari Torbaghan, Karl L. Evans, Markus Fraundorfer,
Nature Communications 2022
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Usability and feasibility assessment of a smartphone application (Suhriday) for heart failure self-care remote monitoring in an Indian tertiary health care setting: a pilot mixed-methods study

Groups and Associations Bhuvana Kolar Bylappa 1, Deepak Y Kamath 2 3, Immaculate Sheela Josephine 3, Jabraan Shaikh 4, Anant Kamath 5, Preethi Rioniz 2, Shruthi Kulkarni 6, Kiron Varghese 4, Denis Xavier 2 3
BMJ Open 2022
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Colchicine and aspirin in community patients with COVID-19 (ACT): an open-label, factorial, randomised, controlled trial

Groups and Associations John W Eikelboom, Sanjit S Jolly, Emilie P Belley-Cote, Alvaro Avezum, Prem Pais, Denis Xavier, Salim Yusuf
The Lancet Respiratory Medicine 2022
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A novel kidney disease index reflecting both the albumin-to-creatinine ratio and estimated glomerular filtration rate predicted cardiovascular and kidney outcomes in type 2 diabetes

Groups and Associations Hertzel C Gerstein, Chinthanie Ramasundarahettige, Ignacio Conget, William C Cushman, Edward Franek, Ibrahim Turfanda, Denis Xavier
Cardiovascular Diabetology 2022
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Use of Mobile Phones in Patients with Stroke

Groups and Associations Alvina, ; Paul, Adithya Philip; Faruqui, Atiya R.
MAMC Journal of Medical Sciences 2022
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The Cost Implications of a Polypill for Primary Prevention in the TIPS-3 Trial

Groups and Associations Andre Lamy, Wesley Tong, Philip Joseph, Peggy Gao, Prem Pais, Tony Dans, Denis Xavier, Shamim Talukder, Anwar Santoso, Habib Gamra, Salim Yusuf
Eur Heart Journal - Quality of Care and Clinical Outcomes 2022
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Association of Psychosocial Stress With Risk of Acute Stroke

Groups and Associations Catriona Reddin, Robert Murphy, Graeme J Hankey, Conor Judge, Denis Xavier, Annika Rosengren
JAMA Network Open 2022
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Patterns of Drug Use and Adverse Drug Reactions in Patients with Autoimmune Bullous Disease (AIBD).

Groups and Associations S.B. Nishitha, , Anuradha S, , Mary Augustine
International Journal of Current Pharmaceutical Review and Research 2022
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Quality of Life in Patients with Autoimmune Bullous Disease (AIBD).

Groups and Associations S.B. Nishitha, , Anuradha S, , Mary Augustine
International Journal of Current Pharmaceutical Review and Research 2022
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Alcohol Intake as a Risk Factor for Acute Stroke: The INTERSTROKE Study

Groups and Associations Andrew Smyth, Martin O'Donnell, Sumathy Rangarajan, Graeme J Hankey, Shahram Oveisgharan, Michelle Canavan, Clodagh McDermott, Denis Xavier
Neurology 2022
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Patterns of medication use and their determinants in pregnancy among women admitted to the obstetrics ward of a tertiary care hospital: A cross sectional study

Groups and Associations Boney Rajan, Elaina Pasangha, Shirley George, Padmini Devi
Journal of Pharmacology and Pharmacotherapeutics 2023
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Secondary prevention with a structured semi-interactive stroke prevention package in INDIA (SPRINT INDIA): a multicentre, randomised controlled trial

Groups and Associations Jeyaraj Durai Pandian, Mahesh Pundlik Kate, Padmavathyamma Narayanapillai Sylaja, Dheeraj Khurana, … Prem Pais, Denis Xavier, Parthasarathy Satishchandra,
The Lancet Global Health 2023
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Effects of a polypill, aspirin or both on cognitive and functional outcomes. A randomised clinical trial

Groups and Associations Bosch JJ, O’Donnel, Gao P, Joseph P, Pais P, Xavier D, Dans A, Lopez J & Yusuf S.et al
Jama Neurology 2023
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Effects of aspirin on cardiovascular outcomes in patients with chronic kidney disease

Groups and Associations Johannes FE Mann, Philip Joseph, Peggy Gao, Prem Pais, Jessica Tyrwhitt, Denis Xavier, Salim Yusuf et al
Kidney International 2023
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Vitamin D supplementation and adverse skeletal and non-skeletal outcomes in individuals at increased cardiovascular risk: Results from the International Polycap Study (TIPS)-3

Groups and Associations P Joseph, P Pais, P Gao, K Teo, D Xavier, P Lopez-Jaramillo, K Yusoff, A Santoso, H Gamra, SH Talukder, C Christou, G Dagenais, J Tyrwhitt, J Bosch, A Dans, S Yusuf
Nutrition, Metabolism and Cardiovascular Diseases 2023
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Depressive Symptoms and Risk of Acute Stroke: INTERSTROKE Case-Control Study

Groups and Associations Robert P Murphy, Catriona Reddin, Annika Rosengren, Conor Judge, Graeme J Hankey, … Albertino Damasceno, Denis Xavier, Alvaro Avezum, Xingyu Wang, Peter Langhorne, Salim Yusuf
Neurology 2023
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Strategies for Promoting Research among Endocrinologists in Private Practice

Groups and Associations Chopra, Denis Xavier, Belinda George, Ganapathi Bantwal, Rakesh Sahay, KVS Hari Kumar, SV Madhu, Saptarshi Bhattacharya
Indian Journal of Endocrinology and Metabolism 2023
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Sleep Patterns and the Risk of Acute Stroke: Results from the INTERSTROKE International Case-Control Study

Groups and Associations Christine Eileen Mc Carthy, Salim Yusuf, Conor Judge, Graeme J Hankey, Helle Klingenberg Iversen, Annika Rosengren, Alvaro Avezum, Patricio Lopez-Jaramillo, Denis Xavier
Neurology 2023
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Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery: An International Randomised Controlled Trial

Groups and Associations Maura Marcucci, Thomas W Painter, David Conen, Vladimir Lomivorotov, Daniel I Sessler, Matt, Denis Xavier, Gordon Guyatt, Salim Yusuf, PJ Devereaux
Annals of Internal Medicine 2023
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Characteristics, clinical practice patterns and outcomes of strokes in India: INSPIRE-A multicentre prospective study

Groups and Associations Denis Xavier, Robert Murphy, Prem Pais, Jeyaraj Pandian, Sarma RK Gosala, Nandini Mathur, Dheeraj Khurana, R Sundararajan
International Journal of Stroke 2023
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An Observational Multi-centric COVID-19 Sequelae Study among Health Care Workers

Groups and Associations Ajay Kumar Shukla, Shubham Atal, Aditya Banerjee, Ratinder Jhaj, Sadasivam Balakrishnan, Preeta Kaur Chugh, Denis Xavier, Atiya Faruqui, Aakanksha Singh
The Lancet Regional Health-Southeast Asia 2023
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A randomised controlled trial evaluating a theory-driven, complex intervention centred on task sharing and mobile health to improve self-care and outcomes in heart failure

Groups and Associations DY Kamath, J Abdullakutty, BB Granger, S Kulkarni, KB Bhuvana, LJ Salazar, S Shifra, J Idiculla, J Narendra, K Varghese, D Xavier
American Heart Journal Plus: Cardiology Research and Practice 2023
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Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised Trials

Groups and Associations Rustam Al-Shahi Salman, Jacqueline Stephen, Jayne F Tierney, Steff C Lewis, David E Newby, Adrian R Parry-Jones, Philip M White, Denis Xavier, Jackie Bosch
The Lancet Neurology 2023
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Variations in the prevalence of atrial fibrillation, and in the strength of its association with ischemic stroke, in countries with different income levels: INTERSTROKE case-control study

Groups and Associations Robert Murphy, Albertino Damasceno, Catriona Reddin, Graeme J Hankey, Helle K Iversen, Shahram Oveisgharan, Denis Xavier, Patricio Lopez Jamarillo, Xingyu Wang, Salim Yusuf
International Journal of Stroke 2024
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One-year outcomes after discharge from noncardiac surgery and association between pre-discharge complications and death after discharge: analysis of the VISION prospective cohort study

Groups and Associations Pavel S Roshanov, Matthew TV Chan, Flavia K Borges, David Conen, CY Wang, Denis Xavier, PJ Devereaux
Anesthesiology 2024
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Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study

Groups and Associations Xingyu Wang, Martin J O'Donnell, Allan Sniderman, Graeme J Hankey, Sumathy Rangarajan, Purnima Rao-Melacini, John Ferguson, Denis Xavier, Salim Yusuf
E Clinical Medicine 2024
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Pre-morbid sleep disturbance and its association with stroke severity: results from the international INTERSTROKE study

Groups and Associations Christine E Mc Carthy, Salim Yusuf, Conor Judge, John Ferguson, Graeme J Hankey, Helle Klingenberg Iversen, Annika Rosengren, Okechukwu Ogah, Luísa Avezum, Denis Xavier, Xingyu Wang,
European Journal of Neurology 2024
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Blood pressure variability in acute stroke: Risk factors and association with functional outcomes at 1 month

Groups and Associations Catriona Reddin, Robert Murphy, Graeme J Hankey, Xingyu Wang, Peter Langhorne, Shahram Oveisgharan, Denis Xavier, Conor Judge, … Andrew Smyth, Salim Yusuf
European Journal of Neurology 2024
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Cost-effectiveness analysis of a fixed dose combination pill for primary prevention of cardiovascular disease from an individual participant data meta-analysis

Groups and Associations Andre Lamy, Wesley Tong, Philip Joseph, Mark D Huffman, Prem Pais, Denis Xavier, Alvaro Avezum, Antonio L Dans, Habib Gamra, Salim Yusuf.
E Clinical Medicine 2024
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Markers of Periodontal Disease and risk of Stroke: INTERSTROKE case-control study

Groups and Associations Robert P Murphy, Graeme J Hankey, Conor Judge, Catriona Reddin, Peter Langhorne, Patricio López–Jaramillo, Charles Mondo, Denis Xavier, Xingyu Wang, Salim Yusuf, Martin O'Donnell
Journal of Stroke and Cerebrovascular Diseases 2024
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Tea and coffee consumption and risk of acute stroke: The INTERSTROKE Study

Groups and Associations Andrew Smyth, Graeme J Hankey, Peter Langhorne, Catriona Reddin, Danuta Ryglewicz, Annika Rosengren, Denis Xavier, Michelle Canavan, Salim Yusuf, Martin O’Donnell
International Journal of Stroke 2024
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A sub-study of the POISE-3 randomised trial examined the effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury

Groups and Associations Amit X Garg, Maura Marcucci, Meaghan S Cuerden… María José Martínez-Zapata, Chew Yin Wang, Denis Xavier, … Richard Whitlock, PJ Devereaux
Kidney International 2025
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Carbonated Beverage, Fruit Drink, and Water Consumption and Risk of Acute Stroke: the INTERSTROKE Case-Control Study

Groups and Associations Andrew Smyth, Graeme J Hankey, Albertino Damasceno, Helle Klingenberg Iversen, Shahram Oveisgharan, Fawaz Alhussain, Peter Langhorne, Denis Xavier, …Salim Yusuf, Martin O’Donnell
Journal of Stroke 2024
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Association of Vascular Risk With Severe vs Non-Severe Stroke: An Analysis of the INTERSTROKE Study

Groups and Associations 210. Catriona Reddin, Michelle Canavan, Graeme J Hankey, …Annika Rosengren, Denis Xavier, Salim Yusuf, Martin J O'Donnell
Neurology 2024
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Using Preoperative Race-Free Estimated GFR to Predict Cardiac Events in Major Noncardiac Surgery: Secondary Analysis of Two Large International Studies

Groups and Associations 211. Pavel Roshanov, Michael Walsh, Ngan Lam, Ainslie Hildebrand, … Denis Xavier, Daniel Sessler, Wojciech Szczeklik, Amit Garg, Christian Meyhoff, Joel Parlow, PJ Devereaux
Anesthesia and Analgesia 2025
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Safety and efficacy of tranexamic acid in general surgery

Groups and Associations Lily J Park, Maura Marcucci, Denis Xavier, Maria Jose Martinez-Zapata, ..PJ Devereaux
JAMA Surgery 2025
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Preoperative estimated glomerular filtration rate to predict cardiac events in major noncardiac surgery: a secondary analysis of two large international studies

Groups and Associations Pavel S Roshanov, Michael W Walsh, .. Kate Leslie, Matthew TV Chan, Flavia K Borges, Chew Yin Wang, Denis Xavier, Miriam de Nadal, PJ Devereaux
British Journal of Anaesthesia 2025
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Improving the clinical trial environment and infrastructure: moving from global resolution to action

Groups and Associations Vasee Moorthy, Nandi Siegfried, John Amuasi, Jing Li, Michael Makanga, Karla Soares-Weiser, Sheamini Sivasampu, Denis Xavier, Faiez Zannad, Valerie Snewin
The Lancet Global Health 2025
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District Residency Programme: Experience of a pharmacology resident

Groups and Associations Santhosh V, Faruqui AR
The National Medical Journal of India 2025
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Influence of age on the association of vascular risk factors with acute stroke (INTERSTROKE): a case–control study

Groups and Associations Catriona Reddin, Graeme J Hankey, Albertino Damasceno, Denis Xavier, Patricio Lopez-Jaramillo, Andrew Smyth, Salim Yusuf, Martin O’Donnell
The Lancet Health Longevity 2025
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Effects of a hypotension-avoidance versus a hypertension-avoidance strategy on neurocognitive outcomes after noncardiac surgery

Groups and Associations Maura Marcucci, Matthew TV Chan, Thomas W Painter, … Denis Xavier, Edith Fleischmann, Chew Yin Wang, Christian S Meyhoff, …PJ Devereaux
Annals of Internal Medicine 2025
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The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol

Groups and Associations Michael Walsh, David Collister, Martin Gallagher, … Denis Xavier,…Vivekanand Jha, Ron Wald, Amanda Y Wang, Atiya R Faruqui, Fei Yuan, Shun Fu Lee, Alena Kuptsova, Courtney Christou, PJ Devereaux
Canadian J Kidney Health and Disease 2025
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Prescribing trends of fixed-dose combination of domperidone and proton-pump inhibitor across tertiary care centers in India, is the combination rational?

Groups and Associations Ajay Kumar Shukla, Sameer Uttamrao Khasbage, Ratinder Jhaj, Balakrishnan Sadasivam, Jerin Jose Cherian, Preeta Kaur Chugh, C D Tripathi, Chetna K Desai, Sandhya Kaustubh Kamat, Raakhi Kaliprasad Tripathi, Yashashri Shetty, Suparna Chatterjee, Debaleena Das, Atiya R Faruqui
Indian Journal of Pharmacology 2025
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A critical evaluation of available explicit deprescribing tools for their applicability to Indian elderly patients: a scoping review protocol.

Groups and Associations • Shukla, A.K., Jhaj, R., Shubham Atal, Anindo Majumdar, Mahadev Meena, Sandeep Tiwari, Bushra Siddiqui, Jerin Jose Cherian, Atiya R. Faruqui & Sowparnika Treasa Sabu
Syst Rev 2025
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Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial.

Groups and Associations • Walsh M, Collister D, Gallagher M, Mark PB, de Zoysa JR, Tyrwhitt J, Tennankore K, Reis G, Xavier D, Liu WJ, Zuo L, Wang AY, Félix C, Sola L, Arici M, Villanueva R, Jha V, Précoma D, Rabbat CG, Alavudeen SS, Faruqui AR, López-Flecher M, Pyne L, Wald R, Yuan F, Balasubramanian K, Lee SF, Kuptsova A, Christou C, Devereaux PJ; ACHIEVE Investigators.
Lancet 2025
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A Drug Utilisation study of antihypertensives and anti-diabetics in a tertiary care hospital.

Groups and Associations 1. Denis Xavier, Srishyla MV, Nagarani MA.
International Journal of Basic & Clinical Pharmacology 2018
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Pattern of Drug Use in Hypertension in a Tertiary Hospital: A Cross-Sectional Study in the In-Patient Wards

Groups and Associations Denis Xavier, Noby Mathew, Johnson Pradeep, Prem Pais
Indian Journal of Pharmacology 2001
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Pharmacology of anti-epileptic drugs: A computer-aided teaching module and its evaluation in medical undergraduates

Groups and Associations 5. A. Vishwanathan, D. Xavier, C. Kulkarni
Indian Journal of Pharmacology 2002
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Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction

Groups and Associations Salim Yusuf, Shamir R. Mehta, Rafael Dıaz, Ernesto Paolasso, Prem Pais, Denis Xavier
American Heart Journal 2004
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Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction

Groups and Associations Salim Yusuf, Shamir R. Mehta, Rafael Dıaz, Ernesto Paolasso, Prem Pais, Denis Xavier
American Heart Journal 2004
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Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomised controlled trial

Groups and Associations 11. Mehta SR, Yusuf S, Diaz R, Zhu J, Pais P, Xavier D, et al.
JAMA 2005
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Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation

Groups and Associations Yusuf S, Mehta SR, Xie C, Ahmed RJ, Xavier D, Pais P, et al
JAMA 2005
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Rationale, design, and organisation of the PeriOperative Ischemic Evaluation (POISE) trial: a randomised controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery

Groups and Associations 14. Devereaux PJ, Yang H, Guyatt GH, P. Pais, D. Xavier, Yusuf S, et al
American Heart Journal 2006
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VITATOPS, the VITAmins TO prevent stroke trial: rationale and design of a randomised trial of B-Vitamin therapy in patients with recent transient ischemic attack or stroke

Groups and Associations Hankey GJ, Algra A, Chen C, Wong MC, Cheung R, Xavier D, et al
International Journal of Stroke 2007
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Perspectives on the management of coronary artery disease in India

Groups and Associations Karthik G, Xavier D, Prabhakar D, Pais P
Heart 2007
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Effects of Fondaparinux in patients with ST-segment elevation acute myocardial infarction not receiving reperfusion treatment

Groups and Associations J Oldgren, L Wallentin, R Afzal, P Pais, D Xavier, S Yusuf, et al
European Heart Journal 2008
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Glucose-insulin-potassium (GIK) therapy in patients with ST-segment elevation myocardial infarction: Results of the OASIS-6-GIK trial and the combined analyses of the OASIS-6 and the CREATE-ECLA GIK trials

Groups and Associations Rafael Díaz, Abhinav Goyal, Shamir R. Mehta, Denis Xavier, Prem Pais, Salim Yusuf, et al.
JAMA 2007
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Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data

Groups and Associations Denis Xavier , Prem Pais, P J Devereaux, Changchun Xie, D Prabhakaran, K Srinath Reddy, Rajeev Gupta, Prashant Joshi, Prafulla Kerkar, S Thanikachalam, K K Haridas, T M Jaison, Sudhir Naik, A K Maity, Salim Yusuf; CREATE registry investigators
Lancet . 2008
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Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial

Groups and Associations Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Xavier D, et al.
LANCET 2008
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The need to test the theories behind the Polypill: the rationale behind the Indian Polycap Study

Groups and Associations Xavier D, Pais P, Sigamani A, Pogue J, Afzal R, Yusuf S
Nature Reviews Cardiology 2008
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Polypharmacotherapy for Primary Prevention of Cardiovascular Disease

Groups and Associations Denis Xavier, PJ Devereaux, Abhinav Goyal, Prem Pais, Salim Yusuf
Indian Heart Journal 2008
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Effects of a polypill (polycap) on risk factors in middle-aged individuals without cardiovascular disease (tips): A phase II, double-blind, randomised trial

Groups and Associations Yusuf S, Pais P, Afzal R, Xavier D, Teo K, Eikelboom J, et al.
LANCET 2009
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Dabigatran versus warfarin in patients with atrial fibrillation

Groups and Associations Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Xavier D, et al
The New England Journal of Medicine 2009
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Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke

Groups and Associations O'Donnell M, Xavier D, Diener C, Sacco R, Lisheng L, Pias P, et al.
Neuroepidemiology 2010
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Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study

Groups and Associations O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, et al
LANCET 2010
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Low-Dose vs Standard-Dose Unfractionated Heparin for The Percutaneous Coronary Percutaneous Coronary Intervention in Acute Coronary Syndromes Treated With Fondaparinux: The FUTURA/OASIS-8 Randomised Trial

Groups and Associations Philippe Gabriel Steg, Sanjit S. Jolly, Shamir R. Mehta, Rizwan Afzal, Denis Xavier, Hans-Jurgen Rupprecht, et al
JAMA 2010
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Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial.

Groups and Associations Hans-Christopher Diener, Stuart J Connolly, Michael D Ezekowitz, Lars Wallentin, Paul A Reilly, Denis Xavier, et al
Lancet Neurology 2010
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The polypill in the prevention of cardiovascular diseases. Key concepts, current status, challenges, and future directions

Groups and Associations Lonn E, Bosch J, Teo KK, Pais P, Xavier D, Yusuf S.
Circulation 2010
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Prevalence, risk factors, manifestations, treatments and outcomes of coronary artery disease in Indians: a systematic review

Groups and Associations Rao Mangala, Xavier Denis, Devi Padmini, Sigamani Alben, Prem Pais, Chadha Puneet, et al., on behalf of the AMEND – SR Steering Committee.
Indian Heart Journal 2015
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Translating evidence into policy for cardiovascular disease control in India

Groups and Associations Gupta R, Guptha S, Joshi R, Xavier D.
Health Research Policy Systems 2011
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Prevalence, risk factors, manifestations, treatments and outcomes of coronary artery disease in Indians: a systematic review

Groups and Associations Rao Mangala, Xavier Denis, Devi Padmini, Sigamani Alben, Prem Pais, Chadha Puneet, et al., on behalf of the AMEND – SR Steering Committee.
Indian Heart Journal 2015
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Characteristics and Short-Term Prognosis of Perioperative Myocardial Infarction in Patients Undergoing Noncardiac Surgery: A Cohort Study

Groups and Associations Devereaux PJ, Xavier D, Pogue J, Guyatt G, Sigamani A, Garutti I, et al. on behalf of the POISE (PeriOperative ISchemic Evaluation) Investigators
Annals of Internal Medicine 2011
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