Faculty & Staff

doctor

Dr Sweta Srivastava

PhD- Molecular Biology and Biochemistry- University of Leeds, United Kingdom

Associate Professor & HOD / Molecular Biology & Genetics

languageLanguages

English, Hindi, Bengali, Urdu, Sanskrit
  • Overview
  • Projects
  • Publications
  • Other Contributions

Ph.D- Molecular Biology and Biochemistry- University of Leeds, United Kingdom

Qualification/ Education

  1. PhD- Molecular Biology and Biochemistry- University of Leeds, United Kingdom
  2. MSc. - Human Physiology, Kolkata University, 

Experience

  1. Associate professor and HoD- Div of Molecular Biology and Genetics, St johns medical College and Hospital- (2023- ongoing)
  2. Assistant Professor- Dept of Transfusion Medicine and Immunohematology, St. Johns Medical College and Hospital-(2015-2022)  
  3. Grant Coordinator- National Centre for Biological Sciences (2011-2015)
  4. Associate scientist- ITC R&D (2009-2011)
  5. Post Doctoral Fellow- National Centre for Biological Sciences (2004-2009)

Areas of interest

Disease biology with focus on Cancer Biology

Field of Expertise

Molecular Biology, Cell Signaling and Biochemistry

Fellowship & Membership

  1. Research Associate fellowship- Department of Biotechnology, 2003
  2. Fellowship from the School of Biological Sciences- University of Leeds, UK, 2000-2003
  3. Fellowship from British Federation of Women Graduate- British Federation of Women Graduate, UK, 2000-2001

Extramural portfolios/ Committees

Member of Board of Studies, Garden City Univeristy, Bangaore

Other formal training/certification

Certification in C++/Linux

Institutional portfolios/ Committees

  1. Quality Manager- St. Johns Laboratory Services
  2. Chairperson- Institutional Animal Ethics Committee
  3. Supervisor- NMC Research Laboratory,

  1. Associate professor and HoD- Div of Molecular Biology and Genetics, St johns medical College and Hospital- (2023- ongoing)
  2. Assistant Professor- Dept of Transfusion Medicine and Immunohematology, St. Johns Medical College and Hospital-(2015-2022)  
  3. Grant Coordinator- National Centre for Biological Sciences (2011-2015)
  4. Associate scientist- ITC R&D (2009-2011)
  5. Post Doctoral Fellow- National Centre for Biological Sciences (2004-2009)

Disease biology with focus on Cancer Biology

No groups and associations specified.

S.I. No Project Title Project Lead Year of Initiation Status
1 Summer training program on integrative Molecular Medicine and applied Bioinformatics in oncology Dr Sweta Srivastava 2024 ongoing
2 Transcriptome sequencing-based comparison of Myeloproliferative Neoplasms, with and without driver mutations, to identify molecular targets in triple-negative MPNs for precision therapy development Dr Sweta Srivastava 2023 ongoing
3 Role of RhoC in cancer stem cells maintenance in solid tumors Dr Sweta Srivastava 2021 completed
4 Sputum transcriptomics and serum cytokine profile to identify novel biomarkers to distinguish tobacco smoke and biomass fuel associated chronic obstructive pulmonary disease Dr Uma 2019 completed
5 Serological and cytokine profile in post tubercular chronic pulmonary aspergillosis Dr Priya R 2019 completed
6 Identification and evaluation of the prognostic markers involving Rho/ROCK signaling pathway in radiation response in cervical cancer Dr Sweta Srivastava 2018 completed
7 Understanding the role of immune response in inhibitor development factor VIII treatment in Hemophilia A Dr Cecil Ross 2018 completed
8 RhoC regulates cancer stem cells in cervical carcinoma Dr Sweta Srivastava 2017 completed
9 ROCK2 dependent radiation inducced DNA repair in cervical carcinoma- a translational opportunity Dr Sweta Srivastava 2017 completed
10 To analyze gene copy number variations on derivative chromosome 9 and its implications in clinical response to Imatinib in Chronic Myeloid Leukemia Dr Cecil Ross 2017 completed
11 To enrich CML stem cells and understand their drug sensitivity in vitro Dr Cecil Ross 2016 completed
12 Development of a PCR-based test for the detection of Aspergillus species in broncheolar lavage samples Dr. Jayanthi 2019 completed
13 Expression analysis of GRP78 Dr. Jayanthi 2025 ongoing
14 Unravelling transcriptomic differences in chronic myeloid leukemia responder and non-responder (with and without mutations) to understand the biology of therapy resistance Dr Sweta Srivastava 2024 ongoing

RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer

Groups and Associations Annapurna Pranatharthi, Pavana Thomas, Avinash H Udayashankar, Chandra Bhavani, Srinag Bangalore Suresh, Sudhir Krishna, Jayashree Thatte, Nirmala Srikantia, Cecil R Ross, Sweta Srivastava
Journal of Experimental & Clinical Cancer Research- Springer Nature 2019
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Microarray analysis reveals distinct immune signatures in BCR‑ABL positive and negative myeloproliferative neoplasms

Groups and Associations Cecil Ross, Mugdha Sharma, John Paul ,Sweta Srivastava
Original research article 2021
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Gene expression profiling of CD34+ sorted cells from Myeloproliferative Neoplasm patients

Groups and Associations Mugdha Sharma, Chandra Bhavani, Srinag Bangalore Suresh, John Paul, Lokendra Yadav, Cecil Ross, Sweta Srivastava
Original research article 2021
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MHC-II molecules present RhoC-derived peptides on the surface of tumour cells

Groups and Associations Pavana Thomas, Sweta Srivastava
Original research article 2022
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A simple high-volume culture technique-Good substitute for polymerase chain reaction for the detection of Aspergillus species in bronchoalveolar lavage samples

Groups and Associations Haritha Subhagan, Jayanthi Savio, Priyadarshini Padaki, Sweta Srivastava, Pavana Thomas, Rajeshwari Veerappan, Priya Ramachandran, John Michael Raj Ashok
Original research article 2021
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RhoC in association with TET2/WDR5 regulates cancer stem cells in epigenetically modifyng the expression of pluripotency genes

Groups and Associations Pavana Thomas, Sweta Srivastava, Avinash H Udayashankara, Samyuktha Damodaran, Lokendra Yadav, Boby Mathew, Srinag Bangalore Suresh, Amit Kumar Mandal, Nirmala Srikantia
Original research article 2022
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Aloe Vera alters POSTN expression, abolishes EMT phenotype. And sensitizes radiation in conjunction with atorvastatin in cervical cancer

Groups and Associations P. Thomas , S. Sahoo , S. Mahajan,D.L. Hiremath, A.H. Udayashankara, S. Srivastava
Original research article 2024
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Fubp3 regulates chronic myeloid leukaemia progression through PRC2 complex regulated pak1-erk

Groups and Associations Mugdha Sharma, Seetharam Anandram, Cecil Ross, Sweta Srivastava
Original research article 2023
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RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target

Groups and Associations Thomas P, Pranatharthi A, Ross C, Srivastava S.
J Exp Clin Cancer Res 2019
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High frequency of exon 20 S768I EGFR mutation detected in malignant pleural effusions: A poor prognosticator of NSCLC

Groups and Associations George D'Souza, Chirag Dhar, Vishal Kyalanoor, Lokendra Yadav, Mugdha Sharma , Mohammad Nawaz S, Sweta Srivastava
Cancer Rep (Hoboken) . 2020
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Ally to adversary: mesenchymal stem cells and their transformation in leukaemia

Groups and Associations Sharma M, Ross C, Srivastava S.
Cancer Cell Int . 2019
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An ingenious non-spherical mesoporous silica nanoparticle cargo with curcumin induces mitochondria-mediated apoptosis in breast cancer (MCF-7) cells

Groups and Associations Lakshminarasimhan Harini, Sweta Srivastava , George Peter Gnanakumar, Bose Karthikeyan, Cecil Ross, Vaithilingam Krishnakumar, Velu Rajesh Kannan, Krishnan Sundar, Thandavarayan Kathiresan
Oncotarget 2019
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Circulating nucleic acids: An analysis of their occurrence in malignancies

Groups and Associations Shankar Suraj, Chirag Dhar, Sweta Srivastava
Biomed Rep 2016
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Polyethylenimine-modified curcumin-loaded mesoporus silica nanoparticle (MCM-41) induces cell death in MCF-7 cell line

Groups and Associations Lakshminarasimhan Harini, Bose Karthikeyan, Sweta Srivastava, Srinag Bangalore Suresh, Cecil Ross, Georgepeter Gnanakumar, Srinivasan Rajagopal, Krishnan Sundar, Thandavarayan Kathiresan
IET Nanobiotechnol 2017
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Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention

Groups and Associations Annapurna Pranatharthi, Cecil Ross, Sweta Srivastava
Stem Cells Int 2016
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CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits

Groups and Associations Chitra Pattabiraman, Shiyuan Hong, Vignesh K Gunasekharan, Annapurna Pranatharthi, Jeevisha Bajaj, Sweta Srivastava, H Krishnamurthy, Aswathy Ammothumkandy, Venkat G Giri, Laimonis A Laimins, Sudhir Krishna
Cancer Res 2014
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Notch signaling in CD66+ cells drives the progression of human cervical cancers

Groups and Associations Jeevisha Bajaj 1, Tessy Thomas Maliekal, Eric Vivien, Chitra Pattabiraman, Sweta Srivastava, H Krishnamurthy, V Giri, Deepa Subramanyam, Sudhir Krishna
Cancer Res 2011
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Cancer stem cells: an approach to identify newer therapeutic targets

Groups and Associations Sweta Srivastava, Sudhir Krishna
J Stem Cells 2010
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Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis

Groups and Associations Andrew B Fielding, Eric Schonteich, Johanne Matheson, Gayle Wilson, Xinzi Yu, Gilles R X Hickson, Sweta Srivastava, Stephen A Baldwin, Rytis Prekeris, Gwyn W Gould
EMBO J . 2005
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Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation

Groups and Associations Karthikeyan Veeraraghavalu , Vanitha K Subbaiah, Sweta Srivastava, Oishee Chakrabarti, Ruchi Syal, Sudhir Krishna
J Virol 2005
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High-throughput and label-free screening of red blood cell stiffness: A study of sickle cell disease

Groups and Associations Saurabh Kaushik , Arkabrata Mishra , Roshan Ross , Sweta Srivastava , Cecil R. Ross , Gautam V. Soni
Biosensors and Bioelectronics: X 2025
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No Others Contributions details available.