February 9, 2026
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Molecular Biology & Genetics
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Overview
The Division of Molecular Biology and Genetics stands at the forefront of precision medicine, operating as a dual-purpose entity that integrates complex clinical diagnostics with transformative translational research. Our mission is to provide definitive genomic insights today while engineering the therapeutic breakthroughs of tomorrow.
Our Clinical Diagnostics Service is built on a foundation of rigorous accuracy and comprehensive methodology. We offer a sophisticated spectrum of services, including Cytogenetics and FISH, advanced Genomics and Molecular Diagnostics, and Transplant Immunology. By providing meticulous HLA Typing and CDC Crossmatching, we ensure the highest standards of compatibility and safety for life-saving transplant procedures.
Parallel to our clinical mandate, our research wing is dedicated to dismantling the mechanisms of therapy resistance in aggressive solid tumors. With a primary focus on Cervical, Lung, and Breast cancers, we investigate the molecular signaling that allows malignant cells to evade treatment. Our internationally recognized work on the RhoC and ROCK2 signaling pathways continues to reshape contemporary understanding of metastatic progression.
The caliber of our scientific quest is reflected in our robust funding profile supported by prestigious national and international agencies including DBT, DST, ICMR, VGST, and RGUHS, alongside significant foreign funding partners. By integrating these resources with clinical observations, the Division goes beyond diagnosing disease—we uncover the fundamental biology of cancer to pave the way for next generation targeted therapies.
In addition to our clinical and research excellence, the Division is deeply committed to education and training. We actively teach postgraduate (PG) students, supervise multiple PhD scholars, and host structured internship and observership programs in Molecular Biology and Genetics. Our faculty also guide students undertaking MSc dissertation projects, fostering a rigorous academic environment that nurtures the next generation of scientists and clinician researchers.
Our Team
Lead
Associate Professor & HOD
Ph.D- Molecular Biology and Biochemistry- University of Leeds, United Kingdom
Core Staff
Assistant Professor
Ph.D-Molecular and Cellular Biology of cancer (SJRI-TDU), M.Tech, BE
Assistant Professor
PhD Life Sciences (CSIR-Institute of Genomics and Integrative Biology, New Delhi)
Services
Diagnostic Services - Molecular Biology and Genetics
View MoreProjects
Publications
Beyond the Common Causes of Palmoplantar Keratoderma: Papillon–Lefevre Syndrome with a Unique Mutation
Srinivasa, Sanjanaa; Ballal, Sumedha; Tilak, Preetha1; Murali, Savitha; Jithendriya, Madhukara High-throughput and label-free screening of red blood cell stiffness: A study of sickle cell disease
Saurabh Kaushik , Arkabrata Mishra , Roshan Ross , Sweta Srivastava , Cecil R. Ross , Gautam V. Soni Aloe vera Alters Periostin Expression, Abolishes EMT Phenotype, and Sensitises Cells to Radiation in Conjunction With Atorvastatin in Cervical Cancer
P. Thomas, S. Sahoo, S. Mahajan, D.L. Hiremath, A.H. Udayashankara, S. Srivastava A PRELIMINARY STUDY ON CHROMOSOMAL BREAKAGE ANALYSIS IN FANCONI ANEMIA
Dr Amudha S,Ms Sowjanya Narayan, Dr Veronica Preetha Tilak Distribution of HLA class I and II genetic profiles of Indian population: A regional analysis using 30,027 umbilical cord blood samples
Sureka Rajendran, Ambily Sivadas, Kanaga Ganesan, Georg Gutjahr, Alagupandian Murugan, Ankur Chaturvedi, Nagaraja S Phani, Chirayu Padhiar, Prakash Sadashiv Gambhir CobVar-a comprehensive resource of vitamin B12-associated genomic variants
Suresh NH, Kilpady CA, Kamath AA, Ahmed A, Thomas T, Kurpad AV, Sivadas A. Novel genetic variants associated with stable isotope-based vitamin B(12) bioavailability measurements in healthy Indian adults
Sivadas A, Devi S, Pasanna RM, Dutta U, Sachdev HS, Kurpad AV. Prevalence of cytogenetic and electrophoretic abnormalities in patients suspected of multiple myeloma
Amudha Subramaniam , Saranya Raj, Thashreefa Olakara1 , Jaya Kumari S , Veronica Preetha Tilak The Oral Bioavailability of Vitamin B(12) at Different Doses in Healthy Indian Adults
Kashyap S, Gowda P, Pasanna RM, Sivadas A, Sachdev HS, Kurpad AV, Devi S. Effect of calcium supplementation on reversing metformin-based inhibition of vitamin B(12) bioavailability in healthy adults using a [(13)C] cyanocobalamin tracer - A pilot study
Muralidharan J, Romould GG, Kashyap S, Pasanna R, Sivadas A, Sachdev HS, Kurpad AV, Devi S. Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function
Angom RS, Joshi A, Patowary A, Sivadas A, Ramasamy S, K V S, Kaushik K, Sabharwal A, Lalwani MK, K S, Singh N, Scaria V, Sivasubbu S. Landscape of pharmacogenetic variants associated with non-insulin antidiabetic drugs in the Indian population
Sivadas A, Sahana S, Jolly B, Bhoyar RC, Jain A, Sharma D, Imran M, Senthivel V, Divakar MK, Mishra A, Mukhopadhyay A, Gibson G, Narayan KV, Sivasubbu S, Scaria V, Kurpad AV. The genomic landscape of CYP2D6 variation in the Indian population
Sivadas A, Rathore S, Sahana S, Jolly B, Bhoyar RC, Jain A, Sharma D, Imran M, Senthilvel V, Divakar MK, Mishra A, Sivasubbu S, Scaria V. Whole genome sequencing followed by functional analysis of genomic deletion encompassing ERCC8 and NDUFAF2 genes in a non-consanguineous Indian family reveals dysfunctional mitochondrial bioenergetics leading to infant mortality
Sabharwal A, Gupta V, Kv S, Kumar Manokaran R, Verma A, Mishra A, Bhoyar RC, Jain A, Sivadas A, Rawat S, Jolly B, Mohanty S, Gulati S, Gupta N, Kabra M, Scaria V, Sivasubbu S. Dynamics of MAM in Radiation resistance of cervical cancers
Harini Lakshminarasimhan, Sweta Srivastava. Cytogenetic Abnormalities identified in cases of Amenorrhea
Christy Vijay, Preetha Tilak, Amudha S, Mary Margaret, Raina P Atypical case of Naxos Syndrome with anhidrosisfrom India
S. Mathew, S. Murali, M. Augustine, S. Ballal, V. P. Tilak CYTOGENETICS OF MULTIPLE MYELOMA
Amudha. S, Drishya Rangaraj, Veronica Preetha Tilak, Bioavailability and daily requirement of vitamin B(12) in adult humans: an observational study of its colonic absorption and daily excretion as measured by [(13)C]-cyanocobalamin kinetics
Kurpad AV, Pasanna RM, Hegde SG, Patil M, Mukhopadhyay A, Sachdev HS, Bhat KG, Sivadas A, Devi S. Maternal Vitamin A Status as a Risk Factor of Hirschsprung Disease in the Child
Hegde SG, Devi S, Sivadas A, Shubha AM, Thomas A, Mukhopadhyay A, Kurpad AV. Multi-omics Analysis Classifies Colorectal Cancer into Distinct Methylated Immunogenic and Angiogenic Subtypes Based on Anatomical Laterality
R I A, Vatsyayan A, Damodaran D, Sivadas A, Van der Speeten K. Cytogenetic Abnormalities identified in cases of Amenorhea.
Christy Vijay, Preetha Tilak, Amudha S, Mary Margaret, Raina P. SIBLING ASSOCIATION IN ANDROGEN INSENSITIVITY SYNDROME- A CASE REPORT
Amudha S, Raina J, Mary A, Preetha Investigating miRNA signatures in metastatic breast cancer: An in-silico analysis
Dr. L. Harini, Dr. Sweta Srivastava Genetic mutations reported in patients of consanguineous and non-consanguineous marriages who presented at a tertiary Health Center for Genetic Counseling
Christy Vijay, Abhay Joseph , Preetha Tilak , Thanmayi GS , Naveen Ramesh Fubp3 regulates chronic myeloid leukaemia progression through PRC2 complex regulated pak1-erk
Mugdha Sharma, Seetharam Anandram, Cecil Ross, Sweta Srivastava Multi-omics analyses provide novel biological insights to distinguish lobular ductal types of invasive breast cancers
Sivadas A, Kok VC, Ng KL. Pharmacogenomic landscape of Indian population using whole genomes
Sahana S, Bhoyar RC, Sivadas A, Jain A, Imran M, Rophina M, Senthivel V, Kumar Diwakar M, Sharma D, Mishra A, Sivasubbu S, Scaria V. RhoC in association with TET2/WDR5 regulates cancer stem cells by epigenetically modifying the expression of pluripotency genes
Pavana Thomas, Sweta Srivastava, Avinash H Udayashankara, Samyuktha Damodaran, Lokendra Yadav, Boby Mathew, Srinag Bangalore Suresh, Amit Kumar Mandal, Nirmala Srikantia A simple high-volume culture technique-Good substitute for polymerase chain reaction for the detection of Aspergillus species in bronchoalveolar lavage samples
Haritha Subhagan, Jayanthi Savio, Priyadarshini Padaki, Sweta Srivastava, Pavana Thomas, Rajeshwari Veerappan, Priya Ramachandran, John Michael Raj Ashok LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy
Sehgal P, Mathew S, Sivadas A, Ray A, Tanwar J, Vishwakarma S, Ranjan G, Shamsudheen KV, Bhoyar RC, Pateria A, Leonard E, Lalwani M, Vats A, Pappuru RR, Tyagi M, Jakati S, Sengupta S, B K B, Chakrabarti S, Kaur I, Motiani RK, Scaria V, Sivasubbu S. Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth
Shivakumar N, Sivadas A, Devi S, Jahoor F, McLaughlin J, Smith CP, Kurpad AV, Mukhopadhyay A. Protocol for a prospective, observational, deep phenotyping study on adipose epigenetic and lipidomic determinants of metabolic homoeostasis in South Asian Indians: the Indian Diabetes and Metabolic Health (InDiMeT) study
Nadiger N, Devi S, Thomas T, Sivadas A, Raj-Kuriyan R, Govindaraj S, Kurpad AV, Mukhopadhyay A. Rare cryptic translocation seen acute myeloid leukemia – A case report
Amudha SubramaniamRaina MetildaPreetha Tilak A simple high-volume culture technique-Good substitute for polymerase chain reaction for the detection of Aspergillus species in bronchoalveolar lavage samples
Haritha Subhagan, Jayanthi Savio, Priyadarshini Padaki, Sweta Srivastava, Pavana Thomas, Rajeshwari Veerappan, Priya Ramachandran, John Michael Raj Ashok Functional characterization of novel variants in SMPD1 in Indian patients with Acid Sphingomyelinase deficiency
Dipti Deshpande, Shailesh Kumar Gupta, Asodu Sandeep Sarma, Prajnya Ranganath , Jamal Md Nurul Jain S, Jayesh Sheth , Mehul Mistri, Neerja Gupta , Madhulika Kabra , Shubha R Phadke , Katta M Girisha , Ratna Dua Puri , Shagun Aggarwal, Chaitanya Datar, Kausik Mandal, Preetha Tilak, Mamta Muranjan, Sunita Bijarnia-Mahay , Radha Rama Devi A, Naresh B Tayade, Akash Ranjan, Ashwin B Dalal Microarray analysis reveals distinct immune signatures in BCR‑ABL positive and negative myeloproliferative neoplasms
Cecil Ross, Mugdha Sharma, John Paul ,Sweta Srivastava Measuring vitamin B-12 bioavailability with [13C]-cyanocobalamin in humans
Devi S, Pasanna RM, Shamshuddin Z, Bhat K, Sivadas A, Mandal AK, Kurpad AV. High frequency of exon 20 S768I EGFR mutation detected in malignant pleural effusions: A poor prognosticator of NSCLC
George D'Souza, Chirag Dhar, Vishal Kyalanoor, Lokendra Yadav, Mugdha Sharma , Mohammad Nawaz S, Sweta Srivastava A Temporal Map of Gene Expression Pattern During Zebrafish Liver Regeneration
Jagtap U, Sivadas A, Basu S, Verma A, Sivasubbu S, Scaria V, Sachidanandan C. Genomics of rare genetic diseases-experiences from India
Anjali Bajaj, Samatha Mathew, Shamsudheen Karuthedath Vellarikkal, Ambily Sivadas, Rahul C. Bhoyar, Kandarp Joshi, Abhinav Jain, Anushree Mishra, Ankit Verma, Rijith Jayarajan, A. Nalini, A. Ravi Kumar, A. T. Arasar Seeralar, Aayush Gupta, Achal K. Srivastava, Aditi Joshi, Aditi Sinha, Aditya Jandial, Afreen Khan, Akhilesh K. Sonakar Population-scale genomics-Enabling precision public health
Sivadas A, Scaria V. Methods to Study Long Noncoding RNA Expression and Dynamics in Zebrafish Using RNA Sequencing
Mathew S, Sivadas A, Sehgal P, Kaushik K, Vellarikkal SK, Scaria V, Sivasubbu S. RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target
Thomas P, Pranatharthi A, Ross C, Srivastava S. RhoC regulates radioresistance via crosstalk of ROCK2 with the DNA repair machinery in cervical cancer
Pranatharthi A, Thomas P, Udayashankar AH, Bhavani C, Suresh SB, Krishna S, Thatte J, Srikantia N, Ross Ally to adversary: mesenchymal stem cells and their transformation in leukaemia
Sharma M, Ross C, Srivastava S. An ingenious non-spherical mesoporous silica nanoparticle cargo with curcumin induces mitochondria-mediated apoptosis in breast cancer (MCF-7) cells
Lakshminarasimhan Harini, Sweta Srivastava , George Peter Gnanakumar, Bose Karthikeyan, Cecil Ross, Vaithilingam Krishnakumar, Velu Rajesh Kannan, Krishnan Sundar, Thandavarayan Kathiresan SAGE: a comprehensive resource of genetic variants integrating South Asian whole genomes and exomes
Hariprakash JM, Vellarikkal SK, Verma A, Ranawat AS, Jayarajan R, Ravi R, Kumar A, Dixit V, Sivadas A, Pharmacogenomic survey of Qatari populations using whole-genome and exome sequences
Sivadas A, Scaria V. RNA secondary structure profiling in zebrafish reveals unique regulatory features
Kaushik K, Sivadas A, Vellarikkal SK, Verma A, Jayarajan R, Pandey S, Sethi T, Maiti S, Scaria V, Sivasubbu S. RNA sequencing of db/db mice liver identifies lncRNA H19 as a key regulator of gluconeogenesis and hepatic glucose output
Goyal N, Sivadas A, Shamsudheen KV, Jayarajan R, Verma A, Sivasubbu S, Scaria V, Datta M. Egyptian tale from India: application of whole-exome sequencing in diagnosis of atypical familial
Sandhya P, Vellarikkal SK, Nair A, Ravi R, Mathew J, Jayarajan R, Kumar A, Verma A, Sivadas A, Danda D, Sivasubbu S, Scaria V. Acute Myeloid Leukemia in a Child with Fanconi Anemia-A Case Report from a Tertiary Care Cancer Center in South India. Hematology & Transfusion.
Anoop Cherungonath, Appaji L, Padma M,Namrata NR, Arunakumari BS, Arun kumar AR, Avinash T, Circulating nucleic acids: An analysis of their occurrence in malignancies
Shankar Suraj, Chirag Dhar, Sweta Srivastava High-throughput and label-free screening of red blood cell stiffness: A study of sickle cell disease
Saurabh Kaushik , Arkabrata Mishra, Roshan Ross , Sweta Srivastava , Cecil R. Ross, Gautam. Soni Polyethylenimine-modified curcumin-loaded mesoporus silica nanoparticle (MCM-41) induces cell death in MCF-7 cell line
Lakshminarasimhan Harini, Bose Karthikeyan, Sweta Srivastava, Srinag Bangalore Suresh, Cecil Ross, Georgepeter Gnanakumar, Srinivasan Rajagopal, Krishnan Sundar, Thandavarayan Kathiresan Comparative Genomic Analysis of Haemophilus haemolyticus and Nontypeable Haemophilus influenzae and a New Testing Scheme for Their Discrimination
Hu F, Rishishwar L, Sivadas A, Mitchell GJ, Jordan IK, Murphy TF, Gilsdorf JR, Mayer LW, Wang X. Landscape of warfarin and clopidogrel pharmacogenetic variants in Qatari population from whole exome datasets
Sivadas A, Sharma P, Scaria V. Chamber Specific Gene Expression Landscape of the Zebrafish Heart
Singh AR, Sivadas A, Sabharwal A, Vellarikal SK, Jayarajan R, Verma A, Kapoor S, Joshi A, Scaria V, Sivasubbu S. Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea Attention
Annapurna Pranatharthi, Cecil Ross, Sweta Srivastava Omic personality: implications of stable transcript and methylation profiles for personalized medicine
Tabassum R, Sivadas A, Agrawal V, Tian H, Arafat D, Gibson G. A Comprehensive Online Resource for Zebrafish Long Non-Coding RNAs
Dhiman H, Kapoor S, Sivadas A, Sivasubbu S, Scaria V. Computational approaches towards understanding human long non-coding RNA biology
Jalali S, Kapoor S, Sivadas A, Bhartiya D, Scaria V. Short stories on zebrafish long noncoding RNAs
Haque S, Kaushik K, Leonard VE, Kapoor S, Sivadas A, Joshi A, Scaria V, Sivasubbu S. CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits
Chitra Pattabiraman, Shiyuan Hong, Vignesh K Gunasekharan, Annapurna Pranatharthi, Jeevisha Bajaj, Sweta Srivastava, H Krishnamurthy, Aswathy Ammothumkandy, Venkat G Giri, Laimonis A Laimins, Sudhir Krishna Whole genome sequencing in support of wellness and health maintenance
Patel CJ, Sivadas A, Tabassum R, Preeprem T, Zhao J, Arafat D, Chen R, Morgan AA, Martin GS, Brigham KL, Butte AJ, Gibson G. Androgen insensitivity syndrome: ten years of our experience
Amudha Subramaniam, Rajender Singh, Preetha Tilak, Rema Devi, Mahalingam Kulandaivelu, Thangaraj 46,XY Female: Phenotype-Genotype correlation and Classification.
Subramaniam Amudha, Devi Rema, Tilak Preetha and Mahalingam K (2010) Amenorrhea: Cytogenetic Studies and Beyond.
Merin T, Rema D, Preetha T, Amudha S, Jayalakshamma J and Mary M (2012). Notch signaling in CD66+ cells drives the progression of human cervical cancers
Jeevisha Bajaj 1, Tessy Thomas Maliekal, Eric Vivien, Chitra Pattabiraman, Sweta Srivastava, H Krishnamurthy, V Giri, Deepa Subramanyam, Sudhir Krishna Cancer stem cells: an approach to identify newer therapeutic targets
Sweta Srivastava, Sudhir Krishna Pharmacogenomic landscape of COVID-19 therapies from Indian population genomes
Sahana S, Sivadas A, Mangla M, Jain A, Bhoyar RC, Pandhare K, Mishra A, Sharma D, Imran M, Senthivel V, Divakar MK, Rophina M, Jolly B, Batra A, Sharma S, Siwach S, Jadhao AG, Palande NV, Jha GN, Ashrafi N, Mishra PK, Vidhya AK, Jain S, Dash D, Kumar NS, Vanlallawma A, Sarma RJ, Chhakchhuak L, Kalyanaraman S, Mahadevan R, Kandasamy S, Devi P, Rajagopal RE, Ramya JE, Devi PN, Bajaj A, Gupta V, Mathew S, Goswami S, Prakash S, Joshi K, Kumla M, Sreedevi S, Gajjar D, Soraisham R, Yadav R, Devi YS, Gupta A, Mukerji M, Ramalingam S, Binukumar BK, Sivasubbu S, Scaria V. "Extra Philadelphia in CML due to Isodicentric 22: A case report”
Amudha S.,Sanjukta S. Rao,Sweta Srivastava,Raina M. P.,Mary Margaret A. Consanguinity and chromosomal abnormality
S Amudha, N Aruna, S Rajangam Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis
Andrew B Fielding, Eric Schonteich, Johanne Matheson, Gayle Wilson, Xinzi Yu, Gilles R X Hickson, Sweta Srivastava, Stephen A Baldwin, Rytis Prekeris, Gwyn W Gould Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation
Karthikeyan Veeraraghavalu , Vanitha K Subbaiah, Sweta Srivastava, Oishee Chakrabarti, Ruchi Syal, Sudhir Krishna SRY (Sex Determining Regions in Y) Basis of Sex Reversal in XY Females.
S. Amudha, Sayee Rajangam, K Thangaraj and K Mahalingam No Data available for Book chapters.
No Data available for Books.
No Data available for Other Publications.
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