Publications
for the POISE-2 Investigators. Clonidine in Patients Undergoing Noncardiac Surgery.
P.J. Devereaux, D.I. Sessler, K. Leslie, A. Kurz, M. Mrkobrada, D. Xavier, et al.; Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may prevent perioperative myocardial infarction and death without inducing hemodynamic instability.
