Publications

ABSTRACT Antidepressant treatments like Electroconvulsive therapy act by inducing neuroplastic changes in the brain. It protects against and even reverses some but not all of this stress-induced neurohistological changes.The aim of the study was to quantify the effect of ECS on the length of pyramidal neurons in CA1 region of hippocampus. Thirty Wistar rats were randomly chosen, divided into experimental group (n=15) which received ECS and the other group was control (n=15). Brains were processed with rapid Golgi technique. Length of pyramidal cells was measured in both groups by using neurolucida software. The mean of experimental group was 1368± 81.09 and control was 739±32.12; with p value ˂0.001. Neurohistological effects of ECS, a manifestation of neuroplasticity may be an important contributor for proper re–wiring so necessary for relearning of healthier cognitions, emotional responses and behavioural expressions in psychological disorders. Key Words: Neuroplasticity, Electroconvulsive Seizure, Depression