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Background: Lumbar spine surgery demands intense analgesia. Preemptive multimodal analgesia (MMA) is a novel approach to attenuate the
stress response to surgical stimulus. Aims: The aim of the study was to assess the intraoperative morphine consumption in patients undergoing
lumbar spine surgery. Patients and Methods: A randomized, prospective, double-blind study involving 42 patients belonging to the American
Society of Anesthesiologists Class I and II scheduled to undergo elective lumbar spine surgery were allocated into two groups of 21 each.
Group A (study group) received injection diclofenac sodium, paracetamol, clonidine, and skin infiltration with bupivacaine adrenaline and
Group B (control group) received paracetamol and skin infiltration with saline adrenaline. Preemptive analgesia was practiced in both the
groups. Intraoperative morphine consumption was documented. Statistical Methods: Intraoperative morphine consumption between the two
groups was compared using Mann–Whitney U-test. Postextubation sedation score between the two groups was compared using Chi-square test
and presented as number and percentage. P < 5% was considered statistically significant. Results: Intraoperative morphine consumption was
significantly low in the study group (P < 0.001). Postextubation sedation score was comparable between the two groups. Conclusion: Preemptive
MMA has demonstrated significant morphine sparing effect intraoperatively in patients undergoing lumbar spine surgeries