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Salmonella osteomyelitis is a rare condition, and its presentation as a Brodie’s abscess is extremely rare. A 41-year-old male presented with a

2-year history of intermittent pain and swelling in the right leg after blunt trauma. Radiographs showed a lytic lesion in the tibial mid-shaft,

suggestive of osteomyelitis; magnetic resonance imaging (MRI) showed a large area of signal change in the tibial diaphysis. A surgical excision

was performed, and the purulent material removed was positive for growth of Salmonella typhi. Due to a significant posteromedial defect after

bone excision, a biocomposite bone substitute was added, and an external fixator was applied to allow immediate ambulation. Subsequent

detailed history and blood tests did not show evidence of typhoid infection. At the 6-month follow-up, there was complete resolution of

symptoms, with no signs of infection or recurrence on subsequent radiographs. This case highlights the importance of identifying Salmonella

as a possible cause of osteomyelitis, even in individuals with no such history. We present a detailed literature review of all published cases of

Salmonella-induced Brodie’s abscess, with special focus on cases in the tibia.