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Role of Adjunctive corticoSTEROIDs on clinical outcomes in severe Scrub typhus pneumonitis: ASTEROIDS study protocol - a randomised controlled trial
Peter JV, Venkatesh B, Premkumar PS, Chacko B, Gunasekaran K, Krishna B, Chaudhry D, Saravu K, Wyawahare M, Ray S, Chandiraseharan VK, Carey R, Rathinam J, Varghese GM Abstract
Introduction Recent studies have demonstrated a beneficial role of steroids in severe community-acquired pneumonia, severe COVID-19 infection and acute respiratory distress syndrome (ARDS) of diverse aetiology. This multicentre randomised controlled trial in severe scrub typhus pneumonitis and ARDS will compare the effects of 6 mg of dexamethasone once per day with placebo, in addition to standard treatment, on ventilator-free days (VFD), mortality and ventilatory requirement.
