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Projects
Reduced Volume and Faster Infusion Rate of Activated Prothrombin Complex Concentrate: A Phase 3b/4 Trial in Adults with Hemophilia A with Inhibitors.
Bülent Zülfikar 1, Johnny Mahlangu 2, Salim Mohamed Nekkal 3, Cecil Ross 4, Noppacharn Uaprasert 5,6, Jerzy Windyga 7, Carmen Escuriola Ettingshausen 8, Bettina Ploder 9, Aurelia Lelli 10, Hanna T Gazda 11,✉ Abstract
Background Activated prothrombin complex concentrate (aPCC) is indicated for bleed treatment and prevention in patients with hemophilia with inhibitors. The safety and tolerability of intravenous aPCC at a reduced volume and faster infusion rates were evaluated.