Ralstonia Mannitolilytica (RM) is a rare opportunistic pathogen capable of causing a serious infection in immunocompromised patients. It is ubiquitous in nature and a frequent contaminant of water supplies. RM infection in cancer patients may have serious implications as they are already susceptible due to underlying malignancy, treatment related immunosuppression, malnutrition and prolonged presence of indwelling central catheters. In this study, we report a case series of RM infection with focus on clinical characteristics, management and patterns of antibiotic sensitivity.