Our Institutions
St. John's Medical College
St. John's College of Nursing
St. John's Allied Health Science
St. John's Medical College Hospital
St. John's Research Institute
SJMCH @Brigade Meadows
St John’s Geriatric Centre
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Projects
Mantle cell lymphoma: Clinical review of changing treatment paradigms with the advent of Novel therapies and an insight into Indian data.
Radhakrishnan VS, Lokireddy P, Parihar M, Prakash PS, Menon H. Mantle cell lymphoma (MCL) is a rare type of mature B-cell lymphoid malignancy with the pathologic hallmark of translocation t(11;14) (q13, q32), which leads to an overexpression of Cyclin D1 (CCND1). The disease is also characterized by the presence of a high number of recurrent genetic alterations, which include aberrations in several cellular pathways. MCL is a heterogeneous disease with a wide range of clinical presentations and a majority presenting with aggressive disease in advanced stages.
