MOG associated antibody disease can have several atypical presentations like pseudotumorcerebri, encephalitis, seizures, small vessel vasculitis, relapsing lumbosacral myeloradiculitis and aseptic meningitis. Here we report a case of a 54- year- old man presenting with isolated limbic encephalitis during his fourth relapse. Anti MOG antibodies may be included in the work up of seronegative limbic encephalitis.