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Is Silodosin A Better Alternative To Tamsulosin As A Part Of Medical Expulsion Therapy In Patients With Lower Ureteric Calculi: A Comparative Study
Mishra R.P, Singh Vishwajeet, Sankhwar S N, Pavan Kumar SK, Singh RK, Kapoor Sahil, Nayab Danish Abstract Aims: To evaluate the efficacy of Silodosin over Tamsulosin in treatment of uncomplicated lower ureteric calculi
Material&Methods: A prospective , randomized comparative study was conducted from Dec 2022 to June 2023 in which 158 patients who were between the age group of 21 –55 years, who had unilateral, uncomplicated lower ureteric stones ≤ 10mm were registered after ethical clearance and were divided into two groups. Group A received Silodosin (8mg) daily, whereas Group B received Tamsulosin (0.4mg) daily for a maximum period of 6 weeks. The patients were reviewed fortnightly with radiological studies. The primary objective was the stone expulsion rate and the second- the stone expulsion time.
Results:A spontaneous stone expulsion was observed in 65 of the 74patients (87.8%) in Group A and in 49 of the out 76 patients (64.4%) in group B. The stone expulsion rate was significantly higher in Group A than in Group B (p < 0.05). There was also a significant difference between the groups with regards to the mean stone expulsion time . The mean expulsion time was 10.5 ±3.5 days in Group A vs. 16.5 ± 7.5 days in Group B (p <0.05).
Conclusion: With the above results, Silodosin was found to be clinically way superior to Tamsulosin, both in view of the stone expulsion rate and time.
