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Hypertrophic cardiomyopathy is a disease of the cardiac muscle leading to severe debilitating symptoms with relentless progression. Medical options in treating this disease are limited to its early stages, with the disease often becoming resistant to pharmacological interventions. Hypertrophic Cardiomyopathy: A Practical Guide to Diagnosis and Management describes the various sub-types of this condition, including its unique anatomic features, with an emphasis on a therapeutic approach, encapsulating several techniques. Surgical myectomy has become the gold standard of effective treatment. This book also throws light on patient selection, newer surgical techniques, and novel image-based pre-operative planning modalities for surgical myectomy.Surgery for hypertrophic obstructive cardiomyopathy has evolved significantly since 1958, as has the surgeon learning curve. It is vital that the myectomy should be precise and confined to the abnormally hypertrophied myocardium. In this chapter, the authors discuss their techniques of myectomy for the different hypertrophic cardiomyopathy phenotypes.