Projects

Dengue fever is an arboviral disease with a wide spectrum of manifestations, ranging from a benign self-limited course to severe life-threatening illness in the form of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). It is a significant public health issue in countries like India. 1 There are few reports on dengue as a cause of febrile neutropenia (FN). Its diagnosis requires a high index of suspicion, and it has important therapeutic implications. We retrospectively evaluated the profile and outcomes of dengue in adult acute lymphoblastic leukemia (ALL) being treated at our center. The medical records of all cases of febrile neutropenia in patients of acute lymphoblastic leukemia, aged 15years, treated at Tata Memorial Hospital from January 2013 to October 2013 were retrospectively analyzed. A total of eight acute lymphoblastic leukemia patients developed dengue fever and their data were analyzed. Diagnosis of dengue infection was made through screening with a Dengue NS1 antigen, and confirmed with an IgM and IgG capture enzymelinked immunosorbent assay.