Projects

Project Description

Nephrotic syndrome (NS) is a clinical syndrome characterized by severe proteinuria, hypoalbuminemia, and/or presence of edema. The main stay of treatment of NS is steroid therapy. While most children respond to daily prednisolone therapy, failure to respond after 4-6 weeks of compliant steroid therapy is presumed to have steroid-resistant nephrotic syndrome (SRNS). This is seen in about 10% to 20% of all children with the condition. (1) The prevalence of SRNS varies depending on the ethnicity with a prevalence of about 54% among Asians as compared to 20% among European children.(2) SRNS can be classified as initial steroid-resistance - failure to achieve complete remission after 6-weeks initial therapy with prednisolone, or late (secondary) steroid-resistance-Initially steroid-sensitive; steroid resistance in a subsequent relapse.