Projects

Project Description

Primary hyperoxaluria2 (PH2) is a rare autosomal recessive disorder associated with significant morbidity and mortality [1]. In view of defects in glyoxylate metabolism, there is significant endogenous overproduction of oxalate leading to oxalate accumulation in multiple organs of the body including the kidneys. Majority of the affected patients present in childhood and 20% of patients with primary hyperoxaluria type 2 (PH2) progress to end stage kidney disease (ESKD) by the second decade of life [2,3].