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Home / Projects / A 6-month multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety and PK/PD of an age-and body weight-adjusted oral finerenone regimen, in addition to an ACEI or ARB, for the treatment of children, 6 months to <18 years of age, with chronic kidney disease and proteinuria

A 6-month multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety and PK/PD of an age-and body weight-adjusted oral finerenone regimen, in addition to an ACEI or ARB, for the treatment of children, 6 months to <18 years of age, with chronic kidney disease and proteinuria

Project Description

The most common causes of CKD in children are congenital anomalies of the kidneys and urinary tract (CAKUT), followed by glomerular and systemic immunological diseases (1). Globally, the prevalence of CKD stage 2 or higher in children ranges between 29.8 and 90.0 per million children. The annual incidence in European countries ranges from 8.7 to 17.5 cases per million (2).

Project Duration

2025 - 2027

Project Lead

Dr. Nivedita Kamath

Authors

Dr. Nivedita Kamath, Dr. Priya Pais

Project Status

ongoing

Project Type

CT

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